During normal translation, the binding of a release factor to one of the three stop codons (UGA, UAA or UAG) results in the termination of protein synthesis. However, modification of the initial ...
Proceedings of the National Academy of Sciences of the United States of America, Vol. 104, No. 26 (Jun. 26, 2007), pp. 10824-10829 (6 pages) In universal-code eukaryotes, a single-translation ...
A new study finds that at least one Archaea has surprisingly flexibility when interpreting genetic code, which goes against a ...
It has long been assumed that there is only one 'canonical' genetic code, so each word means the same thing to every organism. Now, this paradigm has been challenged by the discovery of large numbers ...
For decades, biology has relied on one central assumption: the genetic code is precise. DNA is transcribed into RNA, RNA is ...
A messenger RNA (mRNA) does more than provide ribosomes a template for creating a sequence of amino acids. It also conveys regulatory information, including so-called stop codons. But just as cars ...
To overcome the inherent challenge of translation termination interference caused by stop codon reprogramming in mammalian cells, researchers from Peking University led by Chen Peng from College of ...
When Daniel Fischer cofounded Tevard Biosciences in 2017, he wasn’t trying to bet on the next hot RNA technology. His interest was more personal. His daughter Natasha has Dravet syndrome, a rare form ...
“This is the first real data point that looks at [stop codon reassignment] in an objective way to ask how common is it,” said Laura Landweber, a professor of ecology and evolutionary biology at ...
Gene editing can repair mutations that prematurely halt protein synthesis, resulting in incomplete peptides that cause various diseases. However, other approaches achieve the same effect without ...
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Ambiguous Stop Codons Expand the Genetic Code in Archaea
The beauty of the DNA code is that organisms interpret it unambiguously. Each three-letter nucleotide sequence, or codon, in a gene codes for a unique amino acid that's added to a chain of amino acids ...
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