A team at UT Southwestern Medical Center has identified a structural trick that lets viruses translate their genetic code inside human cells, even when that code is riddled with “bad” codons the host ...

Transcription and translation are processes a cell uses to make all proteins the body needs to function from information stored in the sequence of bases in DNA. The four bases (C, A, T/U, and G in the ...

A newly developed luciferase-based reporter can detect problems in protein translocation and disulfide bond formation in the endoplasmic reticulum (ER). Inspired by natural mechanisms found in ...

Proteins, one of the smallest building blocks of life on Earth, hold promise for answering some of biology's biggest ...

How does the cell convert DNA into working proteins? The process of translation can be seen as the decoding of instructions for making proteins, involving mRNA in transcription as well as tRNA. But ...

A novel reporter protein has been developed to enable the investigation of protein biogenesis in the ER and its disruption in disease. A recent research collaboration between multiple Japanese ...

The innate immune protein C1q seems to have a thing for neurons. Already implicated in synaptic pruning by microglia, now it is reported to also slow down protein production in neurons of the aging ...

The brain’s ability to do everything from forming memories to coordinating movement relies on its cells producing the right proteins at the right time. But directly measuring this protein production, ...

Advanced proteomics and AI reveal blood protein changes, offering insights into early Alzheimer's detection and differentiation from mild cognitive impairment.