An illustration of antibodies, colored pink and blue, over a white background. Antibodies’ flexible loop structures make them difficult to crack with artificial intelligence. Credit: Ian C.

The Baker lab at the Institute for Protein Design at the University of Washington School of Medicine continues to drive innovation in AI-driven advances for protein design. This time, the team used ...

Textbooks often depict proteins in one conformation, but real life, as usual, is much messier. While some proteins have stable, unchanging structures, many others have intrinsically disordered regions ...

CHAPEL HILL, NC – Understanding how proteins bend, twist, and shape-shift as they go about their work in cells is enormously important for understanding normal biology and diseases. But a deep ...

An MIT-developed AI model has designed dozens of lab-confirmed protein binders for targets long considered out of reach, offering a new tool for drug discovery and ...

For the field of drug development, hitting the right target with atomic precision to achieve therapeutic effect remains the core challenge. While traditional R&D pipelines are dependent on ...

The scientists' new 'binder-tag' technique allows researchers to pinpoint and track proteins that are in a desired shape or 'conformation,' and to do so in real time inside living cells. The ...