Ozempic has been making headlines for its remarkable success in treating obesity and diabetes. Yet it is just one in a rapidly growing class of drugs called peptide therapeutics that sits between ...
Chemical synthesis and peptide ligation techniques have revolutionised the field of protein engineering by enabling the precise construction of peptides and proteins with tailored modifications. These ...
Nature makes amide bonds—the key linkages that string together amino acids in a polypeptide—like a knitting whiz. The ribosome in Escherichia coli bacteria, for example, can make eight amide bonds in ...
The breakthrough could simplify the production of complex proteins used in cancer immunotherapy and other advanced medicines ...
Fortunately, these giant rings are about to become a lot easier to access. Helma Wennemers and her team at ETH Zurich have ...
A team at ETH Zurich developed a new peptide-based organocatalyst that handles macrocycle formation from start to finish.
Many biological functions are regulated by the switching on and off of mechanisms triggered by the matching of a keyhole ...
Scientists at the Ecole Polytechnique Fédérale de Lausanne (EPFL) have addressed a long-standing challenge in the pharmaceutical industry, with the development of a two-step, one-pot method for ...
For decades, a substantial number of proteins, vital for treating various diseases, have remained elusive to oral drug therapy. Traditional small molecules often struggle to bind to proteins with flat ...
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