eLife8d
Paradoxical dominant negative activity of an immunodeficiency-associated activating PIK3R1 variant
This study provides convincing data showing that expression of the PIK3R1(deltaExon11) dominant negative mutation in Activated PI3K Delta Syndrome 1/2 (APDS1/2) patient-derived cells reduces AKT ...
eLife8d
Paradoxical dominant negative activity of an immunodeficiency-associated activating PIK3R1 variant
The authors identify new mechanisms that link a PIK3R1 mutant to cellular signaling and division in Activated PI3 Kinase Delta Syndrom 1 and 2 (APDS1/2). The conclusion that this mutant serves as a ...