p110 autophosphorylation and phosphorylation of p85 downregulate activity of the complex. Two chemical inhibitors have been used to probe the function of PI3K: wortmannin, a fungal metabolite that ...

The PIK3CA gene, which encodes the p110α subunit of phosphoinositide 3-kinase (PI3K), is among the most frequently mutated oncogenes in cancer. These mutations drive tumor progression ...

Phagocytosis is a fundamental mechanism used by the body to resist pathogens and restore physiological homeostasis. Herein, to identify small molecules with anti-inflammatory properties via ...