Type 2 diabetes mellitus (T2DM) is a chronic metabolic disorder with a rapidly increasing global prevalence. It is primarily ...

Rather than the PI3K/AKT pathway mediating single unidirectional ... in turn regulated by mediators such as SRC, insulin-like growth factor (IGF)-I and potentially other molecules 175,176.

[37] Also notable in response to ICV insulin infusion was the serine phosphorylation of hypothalamic Akt (also known as protein kinase B), a major downstream mediator of PI3K signaling. Insulin's ...