Inhibitors of phosphoinositide (PI) 3-kinase (PI3K) are approved to treat cancers and other diseases that feature excessive PI3K signalling. By contrast, drugs to boost PI3K activity are an ...
Pancreatic cancer, also known as pancreatic ductal adenocarcinoma, is one of the most aggressive types of cancer. Despite ...
Despite advancements in diagnostic and therapeutic strategies, hepatocellular carcinoma (HCC) remains a leading cause of cancer-related mortality. Antioxidant-1 (ATOX1) has been implicated in ...
Antioxidant-1 may promote HCC carcinogenesis through the activation of the c-Myb/PI3K/AKT pathway and the inhibition of copper accumulation and oxidative stress. Despite advancements in diagnostic and ...
This is a preview. Log in through your library . Abstract The phosphoinositide 3-kinase (PI3K) pathway represents the most hyperactivated oncogenic pathway in triple-negative breast cancer (TNBC), a ...
Experts in cell signaling at the Babraham Institute have identified how prostate cancer cells achieve cell growth free from the usual growth cues and regulators. This discovery has implications for ...
Low-dose aspirin significantly reduced colorectal cancer recurrence in patients with PI3K pathway gene alterations, nearly halving recurrence rates over three years compared to placebo. The study ...
DDX19A promotes gastric cancer proliferation through PI3K/AKT activation Aug. 27, 2024 ...
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🧬 A biological clock gene protects against inflammation and weight gain
Bmal2 is a biological clock gene. In an article published in Metabolism, scientists show that mice with the Bmal2 gene ...
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