In the context of proliferation, SYK promotes the activation of the lipid-modifying kinase phosphoinositide 3 kinase (PI3K) and its downstream mediator protein kinase B (PKB). In addition ...
More information: Toshinori Yoshioka et al, Delta opioid receptor agonists activate PI3K–mTORC1 signaling in parvalbumin-positive interneurons in mouse infralimbic prefrontal cortex to exert ...
Inhibition of PI3K signaling in tumors has metabolic, pro-apoptotic, and anti-proliferative effects, but relief of potent feedback inhibition of upstream receptors increases their activation and ...
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