The authors show that mouse or human tumours in which the PI3K/Akt pathway is constitutively activated are resistant to dietary restriction whereas other tumours are sensitive. The authors also ...

Phosphatidylinositol 3-kinase (PI3K) is involved in multiple cell processes, including insulin signaling, cell growth, immunity, and brain development. It is activated in a wide variety of cancers ...

The latest research published in Genes & Diseases unveils groundbreaking insights into the role of the aging process and the ...

This finding suggests these cancers may have been driven by tamoxifen-induced activation of the phosphatidylinositol 3-kinase (PI3K) pathway, researchers concluded. Data derived from Kubler K, et ...

This in turn triggers a sequence of signal transduction events that include activation of the Ras/Raf/mitogen-activated protein kinase (MAPK), phosphoinositide 3-kinase (PI3K)–Akt, and signal ...

Upon activation by receptor tyrosine kinases, p110 subunits of Class 1A are relieved of their intermolecular inhibition mechanism (ie, interaction with the p85 subunit of PI3K), and PI3K is ...

Hepatocellular carcinoma (HCC), the most common type of primary liver cancer, is characterized by a high rate of metastasis ...

Activation of the PI3K signaling pathway is highly regulated. PI3K activation is initiated by activated receptor tyrosine kinases such as ErbB family receptors, fibroblast growth factor receptors, ...

A pairing of two experimental drugs inhibits tumor growth and blocks drug-induced resistance in ovarian cancer, according to ...

To explore this, the researchers examined two further models (in mice) of tumor progression driven by genetic activation of the PI3K network: a model that also slowly develops prostate cancer but ...

Targeted inhibition of PI3 kinase/mTOR specifically in fibrotic lung fibroblasts suppresses pulmonary fibrosis in experimental models. ... we showed that administration of the inhibitor in a mouse ...