A multi-institutional team of ovarian biologists and other reproductive specialists reports that putting an oocyte from an older mouse into the follicle of a young mouse can rejuvenate the oocyte, ...

Primordial germ cells, which emerge around day 16 in early human embryos, develop to form oogonia so that eventually, the number of oocytes that are present in an adult female is fixed at birth. After ...

The accumulation of misfolded or damaged proteins in long-lived, non-dividing cells like neurons are linked to neurodegenerative diseases like Alzheimer's. A study now finds that the build-up of these ...

In a new study published in the journal Nature, researchers in Japan report that activating just eight genes for producing gene-controlling proteins is enough to convert mouse stem cells directly into ...

This photo shows a mouse obtained from gPSC4-derived oocytes by IVM and IVF. The mouse is now about one year old. The gPSC4- mice have reproductive ability and produced 13 and 7 pups, respectively, ...

Declining female fertility is a health issue that has received broad global attention. Oocyte quality is the key limiting factor of female fertility, and factors affecting oocyte quality involve the ...

One of the immutable truths about being alive is that we age. This happens at every level, down to our cells. When they divide, our cells copy our DNA into each new cell. But as the weeks, months, and ...

How do immature egg cells maintain genetic quality for decades before they mature? Scientists find unusual safeguards in this quiescent cell that may inform research into fertility. Out of all the ...

Extracellular vesicles have been engineered as enhanced drug vehicles, and have emerged as therapeutic agents showing promising results across various pathological conditions. However, they also play ...