This Collection supports and amplifies research related to SDG 3: Good Health & Wellbeing. The human genome is a vast landscape, with less than 2% of its sequence encoding proteins. For many years, ...

Large-scale human genetics studies have shown that many risk variants for common and complex diseases sit in the non-coding ...

What keeps our cells the right size? Scientists have long puzzled over this fundamental question, since cells that are too ...

Each cell in the body is like a miniscule bowl of genetic soup, holding RNA from thousands of genes. But unlike an actual bowl of soup, which can forgive a little too much or not enough of certain ...

Sequencing nearly half a million genomes, researchers show that most additive genetic influences on height, lipids, and other complex traits are now directly measurable, while pinpointing ultra-rare ...

A new multi-omics approach to unpicking how noncoding gene variants influence the development of common chronic diseases has identified tens of thousands of instances where variants have an impact on ...

A new study details the discovery of rare gene variants that increase the prevalence of Type 2 diabetes in multiple generations of Asian Indian people. The unusual finding is a step toward more ...

The non-coding genome, once referred to as "junk DNA," is now understood to be a fundamental regulator of gene expression and a key factor in understanding complex diseases. Image credit: ...

Researchers at the University of Pennsylvania's Perelman School of Medicine have identified over 1,000 genes that could serve as potential targets for kidney disease treatment, according to a new ...

In a recent study published in the journal Scientific Reports, researchers analyzed whole-exome genetic data from more than 2,000 Ashkenazi Jewish centenarians and their relatives to investigate ...

Dharambir Sanghera, Ph.D., is a professor of pediatric genetics at the University of Oklahoma College of Medicine. “We wanted to study several generations of Asian Indians because understanding ...