Hu and colleagues showed a protein controlling the PI3K/Akt pathway, a pathway targeted by more than 40 anti-tumor drugs, is absolutely required for the synthesis, processing and secretion of insulin.

Hu and colleagues showed a protein controlling the PI3K/Akt pathway, a pathway targeted by more than 40 anti-tumor drugs, is absolutely required for the synthesis, processing and secretion of insulin.

IRF1 was also found to be associated with the impairment of the insulin/IGF signaling pathway. Previous studies have linked the expression of IRF1 with male sex, older age, diabetes, and COVID-19.

In this study, our goal was to 1) evaluate the effect of insulin on HEK293SF-3F6 cell growth in two types of media, 2) boost influenza production with the addition of different concentrations of ...

Study: Personalized molecular signatures of insulin resistance and type 2 diabetes. Image credit: Microgen/Shutterstock.com. A recent study, published in the journal Cell, utilized cutting-edge ...

The hormone adrenomedullin disrupts insulin signaling in blood vessel cells, contributing to systemic insulin resistance in obesity-associated type 2 diabetes, according to a new study. Blocking ...

The FDA called it “a historic day” as insulin and certain other biologic drugs transitioned to a different regulatory pathway. The 10-year transition built into the Biologics Price Competition ...

KEY POINTSThe PI3K/AKT/mTOR pathway is an established oncogenic driver in a variety of tumor types.Inhibitors of this pathway are already in clinical testing, ... however, an intriguing class effect ...

Researchers at the University of Massachusetts Medical School have discovered a new pathway that triggers regeneration of beta cells in the pancreas, a key development that may aid in the ...

Further research is needed to assess the potential of activating FGF19 to treat diabetes and obesity. Researchers at UT Southwestern Medical Center have discovered a hormone pathway, independent ...