Surprise finding sheds light on what causes Huntington’s disease, a devastating fatal brain disorder
New research shows that the mutation is, surprisingly, harmless for decades. But it quietly grows into a larger mutation — until it eventually crosses a threshold, generates toxic proteins, and
Study Unveils Surprising Cause of Brain Cell Death in Huntington's Disease
Scientists at the Broad Institute of MIT and Harvard, Harvard Medical School, and McLean Hospital have discovered a surprising mechanism by which the inherited genetic mutation known to cause Huntington's disease leads to the death of brain cells.
New findings shed light on cause of Huntington's disease progression
A new study of nerve cells affected by Huntington’s disease (HD) reveals that the disease-causing gene slowly expands over time, but doesn't start causing harm until it hits a toxic threshold that rapidly leads to the nerve cell’s death.
Surprising way that genetic mutation causes Huntington's disease changes understanding of the disorder
Scientists at the Broad Institute of MIT and Harvard, Harvard Medical School, and McLean Hospital have discovered a surprising mechanism by which the inherited genetic mutation known to cause Huntington's disease leads to the death of brain cells.
Early brain changes in Huntington’s disease detected two decades before symptoms
Subtle changes in the brain, detectable through advanced imaging, blood and spinal fluid analysis, happen approximately twenty years before a clinical motor diagnosis in people with Huntington's disease,
New Research Sheds Light on the Causes of Huntington’s Disease
If you’ve ever heard of Huntington’s disease, you know how devastating it can be. This hereditary brain disorder slowly robs people of their ability to think, move, and even communicate. The disease’s progression is relentless,
Harvard Medical School1d
New Understanding of How Genetic Mutation Causes Huntington’s Disease
Study explains long-standing question of why Huntington’s disease symptoms typically do not appear until midlife even though ...
Brain changes in Huntington’s disease decades before diagnosis will guide future prevention trials
Subtle changes in the brain, detectable through advanced imaging, blood and spinal fluid analysis, happen approximately twenty years before a clinical motor diagnosis in people with Huntington’s ...
Medical mystery solved: Why do some people develop Huntington's earlier than others?
New genetic research shows why some people develop deadly Huntington's disease earlier than others. The findings could lead to better treatments.
GEN1d
Groundbreaking Huntington Study Reveals Somatic DNA-Repeat Expansion
Published in Cell, the study titled, “Long somatic DNA-repeat expansion drives neurodegeneration in Huntington’s disease,” ...
Nature2y
Huntington's Disease: The Discovery of the Huntingtin Gene
HD is a rare, adult-onset, autosomal dominant, progressive neurodegenerative disease. George Huntington (Figure 1) was the first person to provide a comprehensive description of adult-onset HD in ...
Science Daily7mon
Huntington's Disease News
Nov. 13, 2024 — The Huntington's disease (HD) mutation eventually causes a fatal brain disease in adulthood, but a new study finds that early in life, children with the HD mutation have bigger ...