Understanding human gene function in living organisms has long been hampered by fundamental differences between species.

Researchers at The University of Tokyo developed TECHNO, a two-step genome editing strategy that replaces entire mouse loci ...

Humanized mouse models are essential for investigating human gene function; however, the complete replacement of mouse genes ...

Understanding human gene function in living organisms has long been hampered by fundamental differences between species. Although mice share most ...

In the rapidly advancing field of immuno-oncology research, there has been increasing focus on the utility and optimization of cell humanized mice for translational research. Conventional murine ...

Genetically-humanized FcRn mice provide translational pharmacokinetics (PK) and pharmacodynamics (PD) data for antibody-based therapeutics. The image illustrates a therapeutic antibody (blue) adhering ...

Putting the uniquely human version of a certain gene into mice changed the way that those animals vocalized to each other, suggesting that this gene may play a role in speech and language. Mice make a ...