Factor VII deficiency is a rare, autosomal recessive bleeding disorder marked by reduced levels or dysfunction of coagulation factor VII, a crucial initiator of the extrinsic coagulation cascade.

Once-weekly prophylaxis with efanesoctocog alfa (Altuviiio) led to high sustained factor VIII activity and was effective in preventing bleeding among children with severe hemophilia A, the phase III ...

The bleeding disorder hemophilia A, inherited by one in 5000 males, is caused by the lack or malfunction of a blood coagulating factor, factor VIII, encoded by a gene on the X chromosome. The clotting ...

NovoSeven RT is a prescription drug used to treat certain blood clotting disorders, including hemophilia. The drug is given as an intravenous (IV) infusion, which is an injection into a vein over a ...

Lentiviral vector (LV)–based gene therapy using CD34+ hematopoietic stem cells (HSCs) demonstrated stable factor VIII expression in severe hemophilia A patients, with higher vector copy numbers ...