A recent study published in eLife has uncovered a crucial mechanism in cellular material management: endosome maturation. The research team was led by Dr. Ding Mei and Dr. He Kangmin from the ...

When the D/A values of each endosome (n ≈ 50) were quantified and compared with the standard curve, it revealed a mean pH of 6.3 ± 0.1 (Fig. 4 g, black square) which is consistent with the ...

Still, mechanistic mysteries remain. “How impaired endosome maturation leads to the formation of TDP-43 inclusions in the cytoplasm and nuclear depletion, whatever comes first, are still important ...

E ndosomes, small lipid vesicles that sort and traffic biomolecules between other subcellular compartments and organelles, are critical to a cell’s internal transport network and overall function.

Escaping the endosome. Unfortunately, even when LNPs reach their target cells, the nanoparticles are typically captured by endosomes—tiny protective sacs within the cell.

The invented probe has been developed to successfully monitor with exceptional precision and resolve the complicated multistep process of endosome maturation and to target specific endocytic ...

Furthermore, this study indicates that gradual accumulation of lipid nanoparticles in large endosomes leads to impaired acidification, inhibition of maturation, and disrupted mRNA delivery.

The vesicle is then quickly merged with an endosome, an organelle also frequently referred to as a “sorting station”. From the endosome, the substance is either recycled back to the cell membrane (for ...

A drug that inhibits endosome maturation blocked infection in vitro. The next step is to validate all of our findings in vivo. Can it be that a few neurons in our brain are infected for a long time ...

A recent study by a group of scientists has revealed that a different mechanism is responsible for the formation and maintenance of the cell organelle called endosome that sorts and distributes ...

We demonstrate the ability of this DNA nanomachine to function inside living cells by using it to map spatio-temporal pH changes associated with endosome maturation. Our studies show that it is able ...