Potent, selective ABCC6-targeting positive functional modulator (PFM) improved multiple markers of renal function in animal models of chronic kidney disease (CKD) PFM improved inorganic pyrophosphate ...

Credit: Thinkstock Routine patient information, serology results, and cardiac ultrasound findings can identify patients at high risk for severe coronary artery calcification. Investigators have ...

Chronic kidney disease (CKD) is a progressive condition marked by declining renal function, which predisposes patients to systemic metabolic imbalances. A prominent complication in CKD is vascular ...

The ionic and metabolic impairment observed in chronic kidney disease (CKD) leads to vascular calcification, which can induce cardiovascular events and mortality. Several factors may impact the ...

Patients who form calcium kidney stones are more likely to have higher abdominal aortic calcification (AAC) and lower vertebral bone mineral density (BMD) scores than those who do not develop kidney ...

Renal transplantation does not stop or reverse coronary artery calcification (CAC), according to researchers. In a study that included 150 renal transplant recipients, CAC prevalence increased from 35 ...

BOSTON, May 21, 2025 (GLOBE NEWSWIRE) -- Rectify Pharmaceuticals, Inc., (“Rectify”) a biotechnology company pioneering positive functional modulators (PFMs) that restore and enhance membrane protein ...

Calcium deposits can form in different parts of the body, including the arteries, joints, and skin. Eating foods high in potassium, like bananas and avocados, may help reduce calcium buildup in ...

“These translational results demonstrate that Rectify’s PFM reduces vascular calcification and kidney injury and improves kidney function through enhancement of ABCC6 function,” said Rajesh Devraj, Ph ...