There are several difficulties in using RCT data to study the increased risk of cardiovascular events in patients taking COX-2-selective NSAIDs. None of these RCTs, which were primarily conducted ...

Basically, they increase the pain you feel. NSAIDs work on a chemical level. They block the effects of special enzymes -- specifically Cox-1 and Cox-2 enzymes. These enzymes play a key role in ...

Following the withdrawal of rofecoxib and valdecoxib, the discussion concerning selective cyclo-oxygenase ... a further differentiation of COX-2 inhibitors and NSAIDs in terms of cardiovascular ...

The review of recent developments emphasizes the need for novel selective COX-2 inhibitors that possess improved safety profiles compared to existing NSAIDs, which have been linked to various ...

It differs from non-selective NSAIDs because it targets the COX-2 enzyme, primarily involved in inflammation. Celebrex works ...

Medically reviewed by Marissa Sansone, MD Ibuprofen and meloxicam are both nonsteroidal anti-inflammatory drugs (NSAIDs) that treat inflammation and pain. Meloxicam is a stronger anti-inflammatory ...

Clinical trials of several COX-2 selective and nonselective NSAIDs of up to 3 years duration have shown an increased risk of serious cardiovascular thrombotic events, including myocardial ...

Clinical trials of several COX-2 selective and nonselective NSAIDs of up to 3 years duration have shown an increased risk of serious cardiovascular thrombotic events, including myocardial ...

In the third episode of the NSAIDs saga, we focus on COX-2 inhibition! Did the hopes and dreams of selective COX-2 inhibition pan out? What can the rise and fall of VIOXX teach us about physiology?

[77] Intuitively, the combination of a COX-2-selective NSAID plus a proton pump inhibitor (PPI) should provide effective analgesia and further decrease the risk of upper-GI events compared to a ...