Cell polarity is regulated by independent pathways that are controlled by Wnt- or Cdc42-mediated signalling. Now, glycogen synthase kinase 3 (GSK-3), an established component of the Wnt pathway, is ...
Spatial control of Cdc42 signalling by a GM130–RasGRF complex regulates polarity and tumorigenesis
The small GTPase Cdc42 is a key regulator of polarity, but little is known in mammals about its spatial regulation and the relevance of spatial Cdc42 pools for polarity. Here we report the ...
The activation of hepatic stellate cells (HSCs) from a quiescent state is a cause of liver fibrosis and a therapeutic target. HSCs are resident mesenchymal cells located in the space of Disse, ...
A group led by the Department of Cell Biology at the Kidney Research Center, Niigata University revealed that elevated activity of cdc42 is a critical initiation event leading to proteinuria, and ...
Sticky spots on cell membranes hold onto the master regulator of cell polarity, helping to ensure that the regulatory protein accumulates in high enough concentrations to trigger cell polarity. Over ...
Rho GTPases Cdc42 and RacA share significant sequence homology and are conserved among eukaryotic species. These proteins act as molecular switches in various signal transduction pathways by cycling ...
In mice, the Cdc42 gene is necessary for the correct polarity of Sertoli cells that support sperm production, according to a new study. Findings may accelerate efforts to create a non-invasive ...
MBQ-167 is a first-in-class small molecule and dual targeted inhibitor of over-expression of two proteins (Rac and Cdc42) that enable cancer metastasis and increased resistance to other anti-cancer ...
Recent research indicates that CDC42 plays a role in the pathogenesis of kidney disorders such as congenital nephrotic syndrome or glomerulosclerosis because it is necessary for the correct function ...
Marcus Harrell of the Das Lab won Best Poster at the 2024 Biology Department Retreat, voted by his peers and Biology Faculty members. The abstract to Marcus' poster is included: Title: The Cdc42 GEF, ...
How does the cell organize multi-step cytokinetic processes to successfully separate cells after division? The final step in cell division is cytokinesis, where the cytoplasm divides into two after ...
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